Opportunity is missed by most people because it is dressed in overalls and looks like work. - Thomas Edison
Is your output(rip) linearized?That's the first thing I would look at making sure your calibrations are correctEvery sim process job runs different in my shop, when I have more time I'll explain some of the differences between jobs but we have printed lots of 1000+ runs wet on wet through the entire job. Just yesterday we printed 780 pcs wet on wet 10 colors and never stopped to clean a screen but 2 years ago I would be wiping every 100 pcs. Some jobs we have to wipe every couple hundred pcs due to certain colors I cannot eliminate build up on but that's a problem we are working on right now. But we print quite a bit of seps from myseps and never a problem on long runs. Check out the what have you printed section - both prints I posted today were 300-500 pcs each and we didn't wipe screens once.