You can find rentals online for just about anywhere in the Smokies. A word of advice, though. Don't go on major holidays to any of the resort areas. I took a motorcycle ride up 129 "Tail of the Dragon", over to Pigeon Forge (looks just like 192 in Kissimmee) and up through Gatlinburg on the 4th of July. A two-lane road choked with traffic. Gatlinburg isn't big and it took me an hour to get through it. Got over to 441 just north of Cherokee and it took me another hour to travel a mile where I could jump on the entrance to the Blue Ridge Parkway. Helen, GA is another place that plugs up bad during Octoberfest. Takes a good hour to travel 2 miles or so from outside the city limits. JMHO from my own experience.
Otherwise, as Scobey says, it IS beautiful anytime of year, and generally much more laid back than here in O-town.