We ended up doing just about exactly what Admiral just described except we located the second open head at station 11. With the honeycombs and the smart flashes you can flash before hilite white and don't really need the cool down.
I think head 3 open is a no brainer for us- greaser, ub, flash, smooth for plastisol and for wb/dc it doesn't really matter. We only run without a greaser when our color capacity is pushed. Wish we had 14/16 honestly so we could keep the greaser on all the time but of course we would then get hit with a bunch of orders that would somehow max that press out, seems to be the way that works.
I'm not really into running 2 jobs on one press, much rather 2 presses running one job each but there are certainly times where it would help. The eco has a very good system for this with the even/odd function but I doubt we'll ever use it.