For a large area of a single shade of a color (say 50% opacity in photoshop of said color) I usually will drop it 15-20% AND use as high a mesh count as possible to prevent gain. I always see a little gain from the actual print stroke, and a little gain from the next color squishing (even when flashed). I error on the low side vs the high. If everything ends up being super tight and you only see a little gain, you can adjust flood, angle, pressure, speed, stroke twice, etc to increase gain on press. A lot harder to back off than it is to increase the gain in my opinion.