Working with Corels powerful high speed design and separation capabilities you can design and separate anything with ease. Once you know what tools to work with and how to use them.
If you do not believe that understanding and being able to work color is critical and the guy down the street does he is going to take your clients away. How do I know that? Just talked with a small shop today that took a 5K print job and client away from a big Adobe shop. How did he do that in CorelDRAW he seped the art in HSB and got the design down to 4 colors while the Adobe shop was quoting over 10 colors.
You could separate a design like this manually if you wanted to with the techniques in this video.