Opportunity is missed by most people because it is dressed in overalls and looks like work. - Thomas Edison
Personally I wouldn't use the mixo for sim process and try to stay away from modifying inks for this. RFU Wilflex, QCM, Rutland, etc work very well without modifying assuming everything else is dialed in. I think Pierre likes them though.
Sounds like your using all plastisol on this one. If I remember correctly, you like to use a discharge base, correct?If using a plastisol base, you may also want to check your pallets to see how hot they are. Your first few test prints may have been just right (having the base ink slightly tacky), allowing the wet inks to adhere more so. Now that the pallets might be hotter, you might be over flashing or curing the base causing the ink to be more of a sheet of plastic and allowing the top wet inks to move around a bit/causing dot gain says Dot-Tone. Just another thought.Keep the off contact close as well. It may have started out looking good, but the more ink that builds up, can cause this. Now that I think about it, I'm headed down the road that Alan mentioned. Way too many variables that can cause that. Hard to tell.