Opportunity is missed by most people because it is dressed in overalls and looks like work. - Thomas Edison
Be careful with a plasitsol base, I would recommend a Discharge base if you could. But all the best to you on this journey. You might be able to see what Dot Tone Dan can do with the seps, and possibly make this a straight 6 color Sim Process job, which will give you better color , ease of printing vs. 4CP. "But that is just like my opinion man."
Another vote for discharge base if possible. We also add 15% discharge white to our base. Our base screen is in halftones like a sim process print.We also prefer the 3x strength Union true tone process inks when printing on black or color shirts, they make it much easier to get a more vibrant print. Depending on the seps and the design , you can always switch down to the normal strength inks if the print is over saturated. We will also add in the highlight white last.We print manual as well and the tough thing is keeping your print stroke consistent every time. Team printing can help with this. If you have a second printer or even just someone that can load and unload shirts on press for you, you can set it up so that you only print continusly and it well help get into a rhythm of consistent print strokes.