"He who marches out of step hears another drum." ~ Ken Kesey
I sep in layers usually vs channels. Depends on the art somewhat for me. Probably a habit I should break, but it's what I'm comfortable with and works fine.
I almost always separate in Layers, since the bulk of my work is simple spot colors. Thats just how I learned it.When I do simpro work, I use Ultra Seps. And I am NOT good at it...at all. That is the only channel work I do.I need to step up my game. I have Mitch Different's book, but havent done much with it. (Embarrassed to admit)